Thermo Fisher Scientific Calcium Channel beta-4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• Publications: -

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: -

Product Specifications

Product Specific Information

Immunogen sequence:
EHLGEYLEAY WRATHTTSST PMTPLLGRNL GSTALSPYPT AISGLQSQRM RHSNHSTENS PIERRSLMTS DENYHNERAR KSRNRLSSSS QHSRDHYPLV EEDYPDS

Target Information

This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing.
The protein encoded by this locus plays an important role in calcium channel function by:

• Modulating G protein inhibition
• Increasing peak calcium current
• Controlling alpha-1 subunit membrane targeting
• Shifting voltage dependence of activation and inactivation

Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-110802_Calcium_Channel_beta-4_O00305-1_Rabbit.svg, PA5-110802_Calcium_Channel_beta-4_O00305-1_Rabbit_PDP.jpeg)