Thermo Fisher Scientific Calcium Channel beta-4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Calcium Channel beta-4 protein. Validated for WB and IHC applications. Antigen affinity purified and supplied in PBS with glycerol and sodium azide. Suitable for research use in calcium signaling and epilepsy-...
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- PA5110802
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- pk
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Calcium Channel beta-4. Recombinant protein control fragment (Product #RP-90685) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856213 |
Product Specific Information
Immunogen sequence:
EHLGEYLEAY WRATHTTSST PMTPLLGRNL GSTALSPYPT AISGLQSQRM RHSNHSTENS PIERRSLMTS DENYHNERAR KSRNRLSSSS QHSRDHYPLV EEDYPDS
Target Information
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing.
The protein encoded by this locus plays an important role in calcium channel function by:
- Modulating G protein inhibition
- Increasing peak calcium current
- Controlling alpha-1 subunit membrane targeting
- Shifting voltage dependence of activation and inactivation
Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-110802_Calcium_Channel_beta-4_O00305-1_Rabbit.svg, PA5-110802_Calcium_Channel_beta-4_O00305-1_Rabbit_PDP.jpeg)
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