Thermo Fisher Scientific HIC1 Monoclonal Antibody (1E11)
HIC1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체입니다. Western blot, ICC/IF, ELISA에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 암 관련 유전자 발현 연구 및 종양 억제 단백질 분석에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E11 |
| Immunogen | HIC1 (NP_006488, 396–453 a.a.) full length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
YKSSSEETGS SEDPSPPGGH LEGYPCPHLA YGEPESFGDN LYVCIPCGKG FPSSEQLN
Target Information
Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and its expression is frequently suppressed in leukemia and various cancers due to hypermethylation and transcriptional silencing.
These findings suggest that HIC-1 acts as a tumor suppressor protein mediating transcriptional repression. It is ubiquitously expressed in adult tissues and contains five zinc fingers and an N-terminal BTB/POZ domain.
In other BTB/POZ proteins such as BCL-6 and PLZF, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex to repress transcription. However, HIC-1 does not interact with HDAC components, indicating that its repression function is independent of the POZ/BTB domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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