Thermo Fisher Scientific Catenin, beta (p120) Recombinant Rabbit Monoclonal Antibody (CTNNB1, 2030R)
Recombinant rabbit monoclonal antibody targeting beta-catenin (CTNNB1, 2030R). Validated for WB, IHC, ICC/IF, Flow Cytometry, and Peptide Array. High specificity and reproducibility for cell adhesion and signaling studies. Suitable for various cancer r...
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Thermo Fisher Scientific Catenin, beta (p120) Recombinant Rabbit Monoclonal Antibody (CTNNB1, 2030R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CTNNB1, 2030R |
| Immunogen | Recombinant full-length human beta-catenin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature. Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Beta-catenin, an adherens junction (AJ) protein, is a key component of cell-cell adhesion structures. AJs are essential for maintaining epithelial cell layers by regulating cell growth and adhesion. Beta-catenin interacts with E-cadherin and alpha-catenin, linking the E-cadherin complex to the actin cytoskeleton. It also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways including tyrosine kinases, phosphatases, and Wnt/Wingless.
Beta-catenin is expressed in hair follicle cell types, basal and peripheral matrix cells, and root sheath cells. Aberrant beta-catenin activity has been implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, stimulating transcription of genes such as cyclin D and c-myc, which promote cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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