Thermo Fisher Scientific Clusterin Alpha Recombinant Rabbit Monoclonal Antibody (5I2Q1)
Clusterin Alpha 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot, IHC, ELISA에 사용 가능. 인간 및 생쥐 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적이며 -20°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10,000–1:80,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5I2Q1 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 314–449 of human Clusterin alpha chain (NP_001822.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093802 |
Product Specific Information
Immunogen sequence:
STNNPSQAKL RRELDESLQV AERLTRKYNE LLKSYQWKML NTSSLLEQLN EQFNWVSRLA NLTQGEDQYY LRVTTVASHT SDSDVPSGVT EVVVKLFDSD PITVTVPVEV SRKNPKFMET VAEKALQEYR KKHREE
Target Information
Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA5-51294_Clusterin_Alpha_P10909-1_Rabbit.svg)
(이미지 파일명: MA5-51294_Clusterin_Alpha_P10909-1_Rabbit_PDP.jpeg)
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