Thermo Fisher Scientific Phospho-BCR (Tyr360) Polyclonal Antibody
인산화된 BCR(Tyr360)을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-BCR (Tyr360) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 360 (T-T-Y(p)-R-M) derived from Human Bcr |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554100 |
Product Specific Information
A suggested positive control for Western blot is COS7 cells.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in chronic myelogenous leukemia. The chromosome 22 breakpoint occurs within the BCR gene, producing a BCR-ABL fusion protein encoded by sequences from both BCR and ABL (chromosome 9).
While the BCR-ABL fusion protein has been well studied, the normal BCR gene product’s function remains unclear. It exhibits serine/threonine kinase activity and functions as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-37491_Bcr_P11274-1_Rabbit.svg, PA5-37491_Bcr_P11274-1_Rabbit_PDP.jpeg)
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