Thermo Fisher Scientific RhoB Recombinant Rabbit Monoclonal Antibody (3B10K10)
RhoB 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot과 ELISA에 적합합니다. HEK293 세포에서 발현되었으며, 높은 특이성과 재현성을 제공합니다. PBS 기반 용액 형태로 -20°C에서 보관합니다.
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Thermo Fisher Scientific RhoB Recombinant Rabbit Monoclonal Antibody (3B10K10)
Applications and Tested Dilution
- Western Blot (WB): 1:2,000–1:20,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3B10K10 |
| Immunogen | Synthetic peptide corresponding to amino acids 70–150 of human RhoB (NP_004031.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.07 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094316 |
Product Specific Information
Immunogen sequence:
RPLSYPDTDV ILMCFSVDSP DSLENIPEKW VPEVKHFCPN VPIILVANKK DLRSDEHVRT ELARMKQEPV RTDDGRAMAV R
Target Information
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage.
Although not essential for development, it influences cell adhesion and growth factor signaling in transformed cells.
RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.
It also contributes to the stability and nuclear trafficking of AKT1/AKT, promoting endothelial cell survival during vascular development.
Serves as a tumor suppressor — deletion of RhoB causes tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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