Thermo Fisher Scientific B7-H3 Recombinant Rabbit Monoclonal Antibody (PD00-36)
Thermo Fisher Scientific의 B7-H3 Recombinant Rabbit Monoclonal Antibody (PD00-36)는 인간 CD276 단백질을 표적하는 고특이성 항체입니다. IHC 및 Flow Cytometry에 적합하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 세포막 단백질 검출 및 암 면역 연구에 활용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:5,000
Flow Cytometry (Flow)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PD00-36 |
| Immunogen | Synthetic peptide aa 480–534 of B7-H3 (CD276), UniProt ID: Q5ZPR3-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3092889 |
Product Specific Information
- Positive control: Human lung squamous cell carcinoma tissue, human lung adenocarcinoma tissue, human prostate carcinoma tissue, HEK-293, THP-1
- Predicted band size: 57 kDa
- Subcellular Location: Membrane
Target Information
CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that:
- Induces proliferation of CD4+ and CD8+ T cells
- Enhances generation of cytotoxic T cells
- Stimulates interferon gamma production
Expression can be induced on dendritic cells and monocytes by inflammatory cytokines and is widely found in peripheral tissues including heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms due to gene duplication and differential splicing.
CD276 has therapeutic potential for regulating immune responses to cancer, particularly alongside anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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