Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Rabbit polyclonal antibody against Synaptotagmin 1 for WB and IHC. Recognizes rat and mouse homologs. Lyophilized form, reconstitutable with distilled water. Suitable for studies of synaptic vesicle trafficking and neurotransmitter release mechanisms.
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- OSS00022W
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 10–60 of rat Synaptotagmin 1 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4 °C short term. For long term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2176694 |
Product Specific Information
- Reconstitute with 100 µL of distilled water.
- The antigen is homologous in mouse.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the central nervous system (CNS). It functions as a Ca²⁺ sensor in the regulation of exocytosis and neurotransmitter release.
Studies indicate that Ca²⁺-mediated binding of Synaptotagmin 1 to SNAP25 is essential for Ca²⁺-dependent membrane fusion. Specific residues within the C2B binding domain independently influence endocytic rate and synaptic vesicle size.
Synaptotagmin 1 may regulate membrane interactions during synaptic vesicle trafficking at the active zone. It binds acidic phospholipids requiring both an acidic head group and a diacyl backbone.
Ca²⁺-dependent interactions occur with receptors for activated protein kinase C, while Ca²⁺-independent interactions occur with neurexins, syntaxin, and AP2.
Dysfunction of Synaptotagmin 1 is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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