Thermo Fisher Scientific CHK2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (88%), Rat (88%), Pig (90%), Bovine (88%).
• Positive Control: Jurkat, HeLa.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway.
Mutations in CHK2 have been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins.
Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage.
Chk2 acts as a putative tumor suppressor protein, with mutations in the Chk2 gene linked to Li-Fraumeni syndrome, an inherited cancer associated with TP53 mutations.
Mutations in CHK2 are also thought to confer predisposition to sarcomas, breast cancer, and brain tumors.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.