Thermo Fisher Scientific CHK2 Polyclonal Antibody
CHK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. 인간에 반응하며 Mouse, Rat 등에서도 예측 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Chk2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792502 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (88%), Rat (88%), Pig (90%), Bovine (88%).
- Positive Control: Jurkat, HeLa.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway.
Mutations in CHK2 have been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins.
Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage.
Chk2 acts as a putative tumor suppressor protein, with mutations in the Chk2 gene linked to Li-Fraumeni syndrome, an inherited cancer associated with TP53 mutations.
Mutations in CHK2 are also thought to confer predisposition to sarcomas, breast cancer, and brain tumors.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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