Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (rMYC909)

Applications

• Western Blot (WB): 1–2 µg/mL
• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
• Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL

Product Specifications

Product Specific Information

Does not react with Mouse, Rat, or Chicken.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays critical roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with regulation of cell proliferation and cycle control.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis in different cell types.

Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to terminal regions of target proteins.
Amplification of c-Myc has been found in lung, breast, and colon carcinomas, while N-Myc amplification is linked to neuroblastomas.
Translocation of c-Myc on chromosome 8 to immunoglobulin loci (chromosomes 14, 2, or 22) is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant c-Myc expression occurs in tumors of multiple origins, including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, prostatic, thyroidal, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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