Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (rMYC909)
Thermo Fisher Scientific의 c-Myc Oncoprotein Monoclonal Antibody (rMYC909)는 인간 c-Myc 단백질 검출용 항체로, WB 및 IHC에 적합합니다. Mouse IgG1 monoclonal 형식이며 Protein A/G로 정제된 액상 형태입니다. 세포 증식 및 종양 연구에 활용됩니다.
- 카탈로그번호
- 4609-MSM9-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (rMYC909)
Applications
- Western Blot (WB): 1–2 µg/mL
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rMYC909 |
| Immunogen | A synthetic peptide corresponding to aa 408–439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-Myc, coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Mouse, Rat, or Chicken.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays critical roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with regulation of cell proliferation and cycle control.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis in different cell types.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to terminal regions of target proteins.
Amplification of c-Myc has been found in lung, breast, and colon carcinomas, while N-Myc amplification is linked to neuroblastomas.
Translocation of c-Myc on chromosome 8 to immunoglobulin loci (chromosomes 14, 2, or 22) is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant c-Myc expression occurs in tumors of multiple origins, including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, prostatic, thyroidal, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.