Thermo Fisher Scientific c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC/7150R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
• Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with cell proliferation and regulation.

c-Myc is essential for vasculogenesis and angiogenesis in tumor development. The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, and its deregulated expression can induce apoptosis.

Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either the amino- or carboxy-terminus of target proteins. c-Myc, N-Myc, and L-Myc encoded proteins are involved in cell proliferation, differentiation, and neoplastic processes.

Amplification of the c-Myc gene occurs in several human tumors such as lung, breast, and colon carcinomas. N-Myc amplification is observed in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-Myc expression is also found in colorectal, gastric, hepatic, mammary, ovarian, and various other tumor types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.