Thermo Fisher Scientific SMAD1 Monoclonal Antibody (2E9)

Thermo Fisher Scientific SMAD1 Monoclonal Antibody (2E9)

Applications and Tested Dilutions

• Western Blot (WB): 1:500–1:1,000
• ELISA: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN SHPFPHSPNS SYPNSPGSSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ PMDTNMMAPP LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS

Target Information

The SMAD1 protein belongs to the SMAD family, homologous to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
SMAD1 mediates bone morphogenetic protein (BMP) signals involved in cell growth, apoptosis, morphogenesis, development, and immune response. Upon BMP ligand binding, SMAD1 is phosphorylated by BMP receptor kinase and forms a complex with SMAD4 for transcriptional regulation.
SMAD1 is targeted by SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2) for ubiquitination and proteasome-mediated degradation. Alternative splicing variants encoding the same protein have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.