Thermo Fisher Scientific PDZK1 Monoclonal Antibody (OTI2B4)

Applications

• Western Blot (WB): 1:250–1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells. It plays roles in:

• Coordination of ion transport and second messenger cascades
• Clustering functionally dependent proteins with SLC9A3R1
• Modulating trafficking and activity of membrane proteins
• Involvement in multidrug resistance mechanisms through interaction with ABCC2 and PDZK1IP1
• Potentiating CFTR chloride channel activity
• Connecting SCARB1 with intracellular cholesterol transport and metabolism
• Regulating proximal tubular Na(+)-dependent phosphate cotransport, important for tubule function

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.