Thermo Fisher Scientific Thyroglobulin Recombinant Rabbit Monoclonal Antibody (3I10H1)
Thyroglobulin 단백질을 표적하는 재조합 토끼 단클론 항체로, IHC, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293 세포 발현, Affinity Chromatography 정제. PBS 기반 보존액, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3I10H1 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1000–1100 of human Thyroglobulin (P01266). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911950 |
Product Specific Information
- Target localization: Secreted
- Immunogen sequence:
STLSFYQRRR FSPDDSAGAS ALLRSGPYMP QCDAFGSWEP VQCHAGTGHC WCVDEKGGFI PGSLTARSLQ IPQCPTTCEK SRTSGLLSSW KQARSQENPS P
Target Information
Human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones T4 and T3. Thyroid disorders are largely autoimmune in origin, and anti-thyroglobulin autoantibodies were the first such factor discovered. Anti-hTG is present in all thyroid autoimmune diseases (e.g., Hashimoto thyroiditis, Graves disease), with the highest levels observed in Hashimoto thyroiditis. Anti-hTG is also characteristic of thyroid cancer and can be used for monitoring cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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