Thermo Fisher Scientific TAB1 Recombinant Rabbit Monoclonal Antibody (2W0P2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2W0P2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 405-504 of human TAB1 (Q15750). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TAB1,uniProtId:Q15750-1,ncbiNodeId:9606,antigenRange:405-504,antigenLength:504,antigenImageFileName:MA5-42802_TAB1_Q15750-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42802_TAB1_Q15750-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.95 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911943

Product Specific Information

Positive test controls include: HeLa, 293T, Mouse brain, Rat brain.

Immunogen sequence: VTLSLVMPSQ GQMVNGAHSA STLDEATPTL TNQSPTLTLQ STNTHTQSSS SSSDGGLFRS RPAHSLPPGE DGRVEPYVDF AEFYRLWSVD HGEQSVVTAP

Target Information

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. It can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.