Thermo Fisher Scientific Thyroglobulin Recombinant Rabbit Monoclonal Antibody (0N5X7)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50 - 1:200

-

Immunocytochemistry (ICC/IF)

1:50 - 1:200

-

Product Specifications

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

0N5X7

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 300-450 of human Thyroglobulin (P01266). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Thyroglobulin,uniProtId:P01266-1,ncbiNodeId:9606,antigenRange:300-450,antigenLength:2768,antigenImageFileName:MA5-42810_Thyroglobulin_P01266-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42810_Thyroglobulin_P01266-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911951

Product Specific Information

The target is usually found in the following locations: Secreted.

Immunogen sequence: KCEVERFTAT SFGHPYVPSC RRNGDYQAVQ CQTEGPCWCV DAQGKEMHGT RQQGEPPSCA EGQSCASERQ QALSRLYFGT SGYFSQHDLF SSPEKRWASP RVARFATSCP PTIKELFVDS GLLRPMVEGQ SQQFSVSENL LKEAIRAIFP S

Target Information

The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti-thyroglobulin autoantibodies were the first factor to be discovered. Anti-hTG is found in all thyroid autoimmune diseases (Hashimoto thyroiditis, Graves diseases), with the highest level observed in Hashimoto thyroiditis. Anti-hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.