Thermo Fisher Scientific Phospho-Ku80 (Ser145) Polyclonal Antibody
Phospho-Ku80 (Ser145) 폴리클로날 항체로, 인산화된 Ku80 단백질을 특이적으로 검출합니다. Western blot에 적합하며, 인간 시료에 반응합니다. 고순도 정제 및 안정한 PBS/glycerol buffer에 보관됩니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human XRCC5 (Accession P13010), corresponding to amino acid residues around phosphorylated Ser145 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816622 |
Product Specific Information
This antibody detects endogenous levels of Ku80 only when phosphorylated at Ser145.
Target Information
The Ku80 protein (encoded by XRCC5) is the 80-kDa subunit of the Ku heterodimer, also known as ATP-dependent DNA helicase II or DNA repair protein XRCC5. Ku functions as the DNA-binding component of the DNA-dependent protein kinase complex and works with the DNA ligase IV–XRCC4 complex to repair DNA double-strand breaks via non-homologous end joining and to complete V(D)J recombination. Mutations in this gene can impair DNA repair and recombination, and certain polymorphisms are associated with cancer susceptibility and radiosensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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