Thermo Fisher Scientific Phospho-PDGFRB (Tyr751) Polyclonal Antibody
Phospho-PDGFRB (Tyr751) 폴리클로날 항체로, 인산화된 PDGF Receptor beta를 특이적으로 검출합니다. Western blot 및 IHC(Paraffin) 실험에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 고순도 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDGFRB (Accession P09619), corresponding to amino acid residues around phosphorylated Tyr751 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816614 |
Product Specific Information
This antibody detects endogenous levels of PDGF Receptor beta only when phosphorylated at Tyr751.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The ligand bound to the receptor determines whether the receptor forms a homodimer or heterodimer (with PDGFRA). The PDGFRB gene, located on chromosome 5, is adjacent to genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all potentially involved in 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with the ETV6 leukemia gene results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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