Thermo Fisher Scientific Desmosome/Hemidesmosome Chimeric Recombinant Rabbit Monoclonal Antibody (F12)
Desmosome 및 Hemidesmosome 관련 단백질을 인식하는 F12 클론의 재조합 토끼 단일클론 항체. 인간 시료 반응성, HEK293 발현 시스템 사용, Protein A 정제. 면역형광 및 유세포분석에 적합하며 피부 및 조직 구조 연구에 활용 가능.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Immunomicroscopy (IM)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | F12 |
| Immunogen | F12 was established by fusing peripheral blood lymphocytes derived from a human vulgaris patient with a hetermyeloma cell line. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074519 |
Product Specific Information
F12 recognizes an unknown polypeptide of desmosomal and hemidesmosomal plaques with a molecular weight of 185 kDa, determined by immunoblotting using bovine tongue epithelium extract. Immunoelectron microscopy (IEM) revealed that the antibody binds to the intracellular part of the desmosome.
F12 shares immunochemical properties with autoantibodies found in paraneoplastic pemphigus sera. Pemphigus diseases cause blistering of the skin due to autoantibodies against keratinocyte surface proteins. Autoantibodies in pemphigus vulgaris patients recognize desmoglein 1 (Dsg1), a major glycoprotein of the desmosome complex.
Target Information
Desmosomes and Hemidesmosomes are intercellular junctions that maintain tissue structural integrity under mechanical stress.
- Desmosomes connect neighboring cells via cadherins and intermediate filaments.
- Hemidesmosomes anchor epithelial cells to the extracellular matrix through integrins.
Both are found in tissues such as skin, heart, and muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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