Thermo Fisher Scientific TGF-alpha (Transforming Growth Factor alpha) Monoclonal Antibody (TG86)
TGF-alpha 단백질을 인식하는 TG86 단클론 항체로, 인간·토끼·제브라피시에 반응합니다. IHC, ICC/IF, Flow Cytometry에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 4°C 보관, 연구용 전용 시약입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rabbit, Zebrafish |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TG86 |
| Immunogen | A 10-amino acid synthetic peptide (aa34–43; PPVAAAVVSH) from human TGF alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Formalin-fixed tissue staining: Heat tissue sections in 10 mM Tris Buffer with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor and stimulates proliferation of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and tumor cells, and induces anchorage-independent transformation in cultured cells. Human, murine, and rat TGF-alpha are cross-reactive. TGF-alpha (aa 50) shares 33% homology with EGF, binds EGFR, activates receptor tyrosine phosphorylation, and promotes cell proliferation. It plays a role in tumor initiation by inducing a reversible transformed phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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