Thermo Fisher Scientific ALK Monoclonal Antibody (SP8)
ALK 단백질을 표적하는 Rabbit Monoclonal Antibody (Clone SP8). 인체 및 마우스 시료에서 IHC(P) 및 ICC/IF에 적합. Recombinant fragment 기반 면역원 사용. 뇌 발달 및 종양 관련 ALK 연구용에 최적.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SP8 |
| Immunogen | Recombinant fragment within ALK aa 1350–1500 (sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Tissue culture supernatant/TBS, pH 7.5, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982161 |
Product Specific Information
MA5-14528 targets ALK (Anaplastic Lymphoma Kinase, p80) in IHC (P) and ICC/IF applications.
Shows reactivity with Human and Mouse samples.
The immunogen corresponds to a region spanning the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript.
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangement commonly produces a fusion gene combining ALK (chromosome 2) and nucleophosmin (NPM, chromosome 5).
The resulting NPM-ALK fusion product is oncogenic.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, which are absent in the transforming NPM-ALK product.
ALK shows high sequence similarity to LTK and is crucial for neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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