Thermo Fisher Scientific Estrogen Receptor alpha Monoclonal Antibody (SP1)
에스트로겐 수용체 알파(ERα)를 인식하는 단클론 항체로, 인체 유래 시료에서 높은 특이성과 재현성을 제공. IHC, WB, ICC 등 다양한 응용 가능. 단백질 A로 정제된 비결합형 액상 항체로 안정적 보관 및 운송이 용이.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 31 publications |
| Immunohistochemistry (IHC) | - | View 213 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | View 27 publications |
| Immunocytochemistry (ICC/IF) | 1:25–1:250 | View 10 publications |
| Flow Cytometry (Flow) | 1:200 | View 1 publication |
| Dot blot (DB) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat, Sheep, Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SP1 |
| Immunogen | Synthetic peptide derived from C-terminal of human estrogen receptor alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.015 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981779 |
Product Specific Information
This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. It reacts with ER alpha (67 kDa). No special pretreatment is required for IHC staining.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon estrogen binding, undergoes a conformational change enabling dimerization and binding to estrogen response elements (EREs) in DNA. This interaction regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of the estrogen receptor, alpha and beta, encoded by ESR1 and ESR2 genes. Alternative RNA splicing produces at least four estrogen receptor-alpha isoforms (66, 53, 47, and 35 kDa). Estrogen receptors are expressed in various tissues and are crucial for sexual development, reproductive function, and bone physiology. They are implicated in pathological processes such as breast and endometrial cancers and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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