Thermo Fisher Scientific Phospho-Zyxin (Tyr316) Polyclonal Antibody
Zyxin의 Tyr316 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. PBS 기반 용액, 50% 글리세롤 포함, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZYX (Accession Q15942), corresponding to amino acid residues around phosphorylated Tyr316 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817090 |
Product Specific Information
This antibody detects endogenous levels of Zyxin only when phosphorylated at Tyr316.
Target Information
Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and serve as sites for signal transduction complex assembly. It is a zinc-binding phosphoprotein concentrated at focal adhesions and along the actin cytoskeleton. Zyxin contains an N-terminal proline-rich domain and three LIM domains in its C-terminal region. The proline-rich domain interacts with SH3 domain-containing proteins, while the LIM domains facilitate protein-protein interactions. Zyxin may act as a messenger mediating adhesion-stimulated changes in gene expression and modulating actin bundle organization. Alternative splicing results in multiple transcript variants encoding the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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