Thermo Fisher Scientific Phospho-GRK1 (Ser21) Polyclonal Antibody
GRK1 단백질의 Ser21 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot에 적합하며, 인간, 마우스, 랫트 등 다양한 종에 반응. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C 보관. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GRK1 (Accession Q15835), corresponding to amino acid residues around phosphorylated Ser21 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817087 |
Product Specific Information
Antibody detects endogenous levels of GRK1 only when phosphorylated at Ser21.
Target Information
GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases.
GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin, leading to its deactivation.
Defects in GRK1 are known to cause Oguchi disease 2 (stationary night blindness Oguchi type-2).
GRK1 can be phosphorylated by PKA, which reduces its ability to phosphorylate rhodopsin in vitro.
It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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