Thermo Fisher Scientific Human IL-23 Synthetic Peptide
Human IL-23 단백질의 C-말단 14개 아미노산 서열 기반 합성 펩타이드. PA5-20238 항체의 블로킹 펩타이드로 사용 가능. Assay 조건에 따라 사용 농도 조정. 연구용으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human IL-23.
PEP-0357 can be used as a blocking peptide with polyclonal antibody PA5-20238.
Target Information
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. The p19 subunit, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rβ1 and a novel β2-like receptor subunit with a STAT4 binding domain, termed IL-23R.
IL-23 is secreted by activated mouse and human dendritic cells. Its biological activities differ from IL-12: mouse IL-23 does not induce significant IFN-γ but strongly promotes proliferation of memory T cells and induces IL-17 production.
Human IL-23 induces proliferation of memory T cells and moderate IFN-γ production by naive and memory T cells compared to IL-12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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