Thermo Fisher Scientific Human IL-23 Synthetic Peptide
인간 IL-23 아미노 말단의 16개 아미노산 서열을 기반으로 한 합성 펩타이드. IL-23 폴리클로날 항체 PA5-20239의 블로킹 펩타이드로 사용 가능. 인간 IL-23 관련 연구용으로 적합하며, 액상 형태로 제공. PBS 버퍼 및 BSA 포함, -20°C 보관.
- 판매단위
- pk
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human IL-23.
PEP-0358 can be used as a blocking peptide with polyclonal antibody PA5-20239.
Target Information
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19.
p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rβ1 and an additional, novel β2-like receptor subunit with STAT4 binding domain, termed IL-23R.
IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 does not induce significant amounts of IFN-γ but induces strong proliferation of memory T cells (not naive T cells), whereas IL-12 has no effect on memory cells.
Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17.
Human IL-23 has biological properties less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and moderate levels of IFN-γ production by naive and memory T cells compared to IL-12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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