Thermo Fisher Scientific PATZ1 Monoclonal Antibody (OTI8D6), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The PATZ1 protein contains an A-T hook DNA binding motif that interacts with other DNA binding structures, playing a key role in chromatin remodeling and transcription regulation.
Its Poz domain mediates protein-protein interactions required for transcriptional repression, while zinc-fingers form the DNA binding domain.
PATZ1 acts as a transcriptional repressor and is implicated in small round cell sarcoma through fusion with EWS by inversion of chromosome 22q.
This rearrangement creates a chimeric sequence combining the EWS transactivation domain with the PATZ1 zinc finger domain.
Four alternatively spliced transcript variants have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.