Thermo Fisher Scientific NR1H4 Monoclonal Antibody (OTI4F12), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

FXR (farnesoid X receptor; NR1H4) is a nuclear receptor and ligand-activated transcription factor belonging to the NR1 subfamily. It functions as a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid, and deoxycholic acid. FXR regulates bile acid homeostasis by controlling genes involved in bile acid synthesis, conjugation, and enterohepatic circulation.
Additionally, FXR influences lipid and glucose metabolism and plays a role in innate immune response. The FXR-RXR heterodimer binds to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' (IR-1). In the liver, FXR activates transcription of NR0B2, indirectly inhibiting CYP7A1 and CYP8B1, and regulates genes such as SLC10A1/NTCP, SLC27A5/BACS, BAAT, ABCB11/BSEP, ABCC2/MRP2, and ABCB4, which are involved in bile acid transport and conjugation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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