Thermo Fisher Scientific PDE8B Polyclonal Antibody
Human 및 비인간 영장류에 반응하는 PDE8B 폴리클로날 항체. IHC(P) 검증 완료, 항원 친화 크로마토그래피로 정제. 액상 형태, 0.3 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 5 µg/mL
- 참고: Heat-induced antigen retrieval in pH 6.0 citrate buffer 권장
- 1차 항체 처리 후 biotinylated 2차 항체, alkaline phosphatase-streptavidin 및 chromogen 사용
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from internal region of human PDE8B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550442 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Gibbon, Monkey, Marmoset (100%)
- Dog, Horse (94%)
- Mouse, Rat, Bat, Elephant, Pig (88%)
- Opossum, Platypus (81%)
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5′,3′-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5′-monophosphates.
Mammalian PDEs are grouped into families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies.
The PDE8 family includes high-affinity cAMP-specific, IBMX-insensitive PDEs such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that determines family-specific regulatory properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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