Thermo Fisher Scientific PDGFRB Polyclonal Antibody
PDGFRB 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. IHC(P)에서 20 µg/mL로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 신호전달 및 암 연구 등 다양한 생명과학 연구용으로 적합합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PDGFRB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from extracellular domain of human PDGFRB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550444 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Gibbon (94%); Monkey (88%); Marmoset, Elephant (81%) - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the receptor forms a homodimer or heterodimer (PDGFRA/PDGFRB).
The PDGFRB gene is located on chromosome 5, near the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all potentially linked to the 5-q syndrome.
A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with ETV6 results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.