Thermo Fisher Scientific PDE8A Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 10 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Dog, Panda, Horse, Rabbit, Pig (100%);
Marmoset (94%); Mouse, Rat, Bovine, Elephant, Opossum (88%);
Platypus, Zebrafish (81%).

For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP, which act as second messengers in various physiological processes such as vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction.
PDEs are a large superfamily divided into 10 families, distinguishable by structure, tissue expression, localization, substrate specificity, regulation, and inhibitor sensitivity. Their diversity makes PDEs promising targets for pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.