Thermo Fisher Scientific Phospho-c-Raf (Ser338, Tyr340) Polyclonal Antibody
인간 c-Raf의 Ser338 및 Tyr340 인산화 부위를 인식하는 다클론 항체로, Western blot 및 Immunoprecipitation에 사용 가능. MAPK 신호전달 연구에 적합하며, 비결합형 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: References
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human c-Raf that contains serine 338 and tyrosine 340. The sequence is conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2533671 |
Target Information
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) functioning downstream of the Ras family of membrane-associated GTPases. Once activated, Raf-1 phosphorylates and activates MEK1 and MEK2, which in turn activate ERK1 and ERK2. Activated ERKs regulate gene expression controlling cell division, apoptosis, differentiation, and migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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