Thermo Fisher Scientific RC3H1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

-

Immunohistochemistry (IHC)

5 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

An 18 amino acid peptide near the carboxy terminus of human RC3H1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RC3H1,uniProtId:Q5TC82-1,ncbiNodeId:9606,antigenRange:1133,antigenLength:1133,antigenImageFileName:PA5-34519_RC3H1_Q5TC82-1_Rabbit.svg,antigenImageFileNamePDP:PA5-34519_RC3H1_Q5TC82-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551871

Product Specific Information

A suggested positive control is Hela cell lysate.

PA5-34519 can be used with blocking peptide PEP-1562.

Target Information

The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1- mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.