Thermo Fisher Scientific CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), Alexa Fluor 488, eBioscience

Thermo Fisher Scientific CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), Alexa Fluor 488

Applications and Tested Dilutions

Product Specifications

Available Formats

• Unconjugated
• APC-eFluor 780
• Biotin
• Brilliant Violet 711
• eFluor 450
• eFluor 660
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

The eBio1D4B monoclonal antibody reacts with mouse CD107a, also known as lysosomal-associated membrane protein-1 (LAMP-1). CD107a is a type I lysosomal membrane protein that is extensively glycosylated and expressed constitutively in late endosomes and lysosomes. It is transiently expressed on the surface of degranulating cytolytic T cells and is implicated in cancer metastasis and lysosomal storage disorders.

Applications Reported:

• Intracellular staining followed by flow cytometric analysis
• Surface staining in flow cytometric degranulation assays

Applications Tested:
Tested by intracellular staining and flow cytometric analysis of thioglycolate-induced peritoneal exudate cells. Recommended use ≤ 0.5 µg/test (100 µL final volume). Optimal titration advised.

Additional Details:

• Excitation: 488 nm
• Emission: 519 nm
• Laser: Blue Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

LAMP1 (CD107a) is a major lysosomal membrane component, together with LAMP2. Approximately 1–2% of total CD107a is found on the plasma membrane. LAMP1 is a heavily glycosylated type I integral membrane protein involved in lysosome biogenesis and fusion with phagosomes. Its surface expression is associated with cell activation and adhesion of PBMCs to vascular endothelium, suggesting a role in inflammation. Increased LAMP1 expression is observed around senile plaques in Alzheimer’s disease and in activated mast cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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