Thermo Fisher Scientific FGFR3 Polyclonal Antibody
Rabbit polyclonal antibody against human FGFR3 recombinant protein. Suitable for research use in studying FGFR3 signaling and related pathways. Supplied as liquid, unconjugated form. Store at 4°C short term or -20°C long term. For research use only.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FGFR3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857030 |
Product Specific Information
Immunogen sequence:
GQQEQLVFGS GDAVELSCPP PGGGPMGPTV WVKDGTGLVP SERVLVGPQR LQVLNASHED SGAYSCRQRL TQRVLCHFSV RVTDA
Target Information
FGFR3 (Fibroblast Growth Factor Receptor 3) is a member of the FGFR family of receptor tyrosine kinases. This family regulates various cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. FGFR family members are implicated in diseases such as cancer, rheumatoid arthritis, and diabetic retinopathy.
FGFR family members differ in ligand affinities and tissue distribution. A full-length FGFR3 protein includes:
- Three immunoglobulin-like extracellular domains
- A single hydrophobic membrane-spanning segment
- A cytoplasmic tyrosine kinase domain
The extracellular region binds fibroblast growth factors, triggering downstream signaling that influences mitogenesis and differentiation. FGFR3 plays a critical role in bone development and maintenance. Mutations in this gene are associated with craniosynostosis and various skeletal dysplasias. Three alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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