Thermo Fisher Scientific GP6 Polyclonal Antibody
Human GP6 단백질에 특이적인 Rabbit Polyclonal 항체로, IHC(P)에서 1:500~1:1,000 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 혈소판의 콜라겐 유도 활성화 연구에 적합.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GP6. Recombinant protein control fragment (Product #RP-103633) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857025 |
Product Specific Information
Immunogen sequence:
VTLRCQGPPG VDLYRLEKLS SSRYQDQAVL FIPAMKRSLA GRYRCSYQNG SLWSLPSDQL
Target Information
Glycoprotein VI (GP6) is a 58-kDa platelet membrane glycoprotein that plays a crucial role in collagen-induced activation and aggregation of platelets. Upon vessel wall injury and endothelial damage, exposure of the subendothelial matrix to blood flow results in platelet deposition.
Collagen fibers—especially types I, III, and VI—are the most thrombogenic components of the extracellular matrix. Platelet interaction with collagen occurs in two steps:
- Initial adhesion to collagen
- Activation leading to platelet secretion, recruitment, and aggregation
Under physiological conditions, this platelet plug formation limits blood loss. However, exposure of collagen after rupture of atherosclerotic plaques can trigger thrombus formation, contributing to myocardial infarction or stroke.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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