Thermo Fisher Scientific IGF1 Polyclonal Antibody, PeproTech
Human IGF1에 특이적인 Rabbit Polyclonal Antibody로 Western blot, ELISA, Immunostaining 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 민감도를 제공. 세포 성장, 분화, 생존 연구에 활용 가능.
- 카탈로그번호
- 500-P11-xxx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IGF1 Polyclonal Antibody, PeproTech
Thermo Fisher Scientific IGF1 Polyclonal Antibody, PeproTech
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.2 µg/mL | 2 publications |
| ELISA | 0.5–2.0 µg/mL | - |
| Neutralization (Neu) | - | 1 publication |
| In vitro Assay (IV) | - | 1 publication |
| Immunostaining (IS) | - | 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived Recombinant Human IGF-I |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.1–1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
| RRID | AB_2929255 |
Product Specific Information
AA Sequence of Recombinant Protein:
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Preparation:
Produced from sera of rabbits immunized with highly pure Recombinant Human IGF-I. Anti-Human IGF-I-specific antibody purified by affinity chromatography using immobilized Human IGF-I matrix.
Sandwich ELISA:
For detection of Human IGF-I, use 0.5–2.0 µg/mL antibody solution (100 µL/well). In conjunction with PeproTech Biotinylated Anti-Human IGF-I (500-P11Bt) as detection antibody, enables detection of 0.2–0.4 ng/well Recombinant Human IGF-I.
Western Blot:
Use at 0.1–0.2 µg/mL for detection of Human IGF-I. Detection limit: 1.5–3.0 ng/lane under reducing or non-reducing conditions.
Target Information
IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but exhibits stronger growth-promoting activity. It induces cellular responses such as proliferation, differentiation, migration, and survival across various tissues including muscle, bone, and cartilage.
IGF1 enhances glucose transport and metabolism at lower concentrations than insulin. Circulating IGFs bind to IGFBPs, extending their half-life and aiding tissue targeting.
IGF-I is a potent activator of the AKT signaling pathway, promoting proliferation and inhibiting apoptosis. Mature human IGF-I is 100% homologous with bovine and porcine proteins. Low IGF1 levels are associated with Alzheimer's disease.
Defects in IGF1 gene cause growth factor deficiency, and multiple transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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