Thermo Fisher Scientific PKNOX2 Polyclonal Antibody

Thermo Fisher Scientific PKNOX2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

• Detects endogenous PKNOX2 protein at a molecular weight of 55 kDa.
• Purity >95% by SDS-PAGE.

Target Information

PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family.
PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1 but shows more restricted tissue distribution and a higher DNA-dissociation rate.
Like PREP-1, PREP-2 forms a heterodimer with Pbx 1, which relocates to the nucleus and associates with HoxB1 to form a ternary complex. Unlike PREP-1, which increases transcriptional activation, PREP-2 slightly decreases transcriptional activity of the complex.
Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin, and tubulin/microtubules.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.