Thermo Fisher Scientific ARTS1 Polyclonal Antibody
ARTS1(ERAP1) 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 1 mg/mL 농도, 항원 친화 크로마토그래피로 정제됨. 인간, 생쥐, 랫트 반응성. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 435–489 of human ERAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2553423 |
Product Specific Information
- Detects endogenous protein at molecular weight of 110 kDa
- Purity >95% by SDS-PAGE
Target Information
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the ER lumen. It removes NH₂-terminal residues from antigenic precursors for MHC class I peptide presentation. ERAP1 trims peptides of 9 amino acids or more and is induced by interferon-gamma.
The human ERAP1 gene maps to chromosome 5q15 and is also known as:
- Adipocyte-derived leucine aminopeptidase (A-LAP)
- Puromycin-insensitive leucine-specific aminopeptidase (PILS-AP)
- Aminopeptidase regulator of TNFR1 shedding (ARTS-1)
A-LAP may regulate blood pressure by inactivating angiotensin II. PILS-AP is involved in angiogenesis, and ARTS-1 promotes TNFR1 shedding. Further research is needed to fully understand its functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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