Thermo Fisher Scientific IFNAR1 Recombinant Rabbit Monoclonal Antibody (ARC0262)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0262

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 458-557 of human IFNAR1 (P17181) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IFNAR1,uniProtId:P17181-1,ncbiNodeId:9606,antigenRange:458-557,antigenLength:557,antigenImageFileName:MA5-35051_IFNAR1_P17181-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35051_IFNAR1_P17181-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2848956

Product Specific Information

Immunogen sequence: KVFLRCINYV FFPSLKPSSS IDEYFSEQPL KNLLLSTSEE QIEKCFIIEN ISTIATVEET NQTDEDHKKY SSQTSQDSGN YSNEDESESK TSEELQQDFV

Target Information

Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.