Thermo Fisher Scientific Inhibin, alpha (INHA) (Gonadal Cell Marker) Recombinant Rabbit Monoclonal Antibody (INHA/8872R)
Thermo Fisher Scientific의 INHA/8872R 항체는 인간 Inhibin alpha 단백질을 표적으로 하는 재조합 토끼 단클론 항체입니다. IHC(P)에서 1–2 µg/mL로 사용되며, 생식세포 및 종양 연구에 적합합니다. 단백질 A/G로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INHA/8872R |
| Immunogen | Recombinant fragment of human Inhibin alpha protein (around aa 233–362) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human prostate or testis
- Cellular Location: Nucleus, Cytoplasm (secreted)
Target Information
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin negatively regulates gonadal stromal cell proliferation and exhibits tumor-suppressor activity. Serum inhibin levels correlate with granulosa-cell tumor size, serving as a marker for primary and recurrent disease. In prostate cancer, inhibin alpha-subunit expression is suppressed and undetectable in poorly differentiated tumor cells. Expression varies across tissues, suggesting inhibin functions as both a growth/differentiation factor and a hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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