Thermo Fisher Scientific Phospho-AMPK alpha-1,2 (Ser485, Ser491) Polyclonal Antibody
AMPK α1/α2의 Ser485/Ser491 인산화 상태를 검출하는 폴리클로날 항체. Western blot에 최적화되어 있으며 인간, 마우스, 랫트 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 에너지 대사 연구에 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer491 of human AMPKα2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10986566 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other related proteins.
Target Information
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK).
AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits.
It acts as an energy-sensing enzyme that monitors cellular energy status.
When activated by metabolic stress, AMPK phosphorylates and inactivates ACC and HMGCR, key enzymes in fatty acid and cholesterol biosynthesis.
Mouse studies suggest this catalytic subunit regulates insulin sensitivity and myocardial energy homeostasis during ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-17543_AMPK_alpha-1,2_P54646-1_Rabbit.svg / PA5-17543_AMPK_alpha-1,2_P54646-1_Rabbit_PDP.jpeg)
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