Thermo Fisher Scientific CSF1R Polyclonal Antibody
CSF1R 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에서 검증됨. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로 macrophage 관련 연구에 적합.
- 카탈로그번호
- PA517538
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to carboxy-terminal residues of human M-CSF receptor (CSF1R, CD115; UniProt ID: P07333-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 97 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978500 |
Product Specific Information
- It is not recommended to aliquot this antibody.
Target Information
CSF1R (also known as FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and a member of the CSF1/PDGF receptor family of tyrosine-protein kinases.
Mutations in the CSF1R gene are associated with a predisposition to myeloid malignancy.
This receptor acts as a cell-surface receptor for CSF1 and IL34, playing an essential role in the regulation of survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes such as macrophages and monocytes.
It promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and inflammatory processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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