Thermo Fisher Scientific HLA-G Monoclonal Antibody (MEM-G/9)

Thermo Fisher Scientific HLA-G Monoclonal Antibody (MEM-G/9)

Applications and Tested Dilutions

Product Specifications

Available Conjugated Formats

• APC
• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope on the native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form.
Reactivity with HLA-G3 was also reported. It will not cross-react with mouse.

Target Information

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane.
HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons.
Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.