Thermo Fisher Scientific PROZ Monoclonal Antibody (OTI3E5), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PROZ (Protein Z) is a vitamin K-dependent plasma glycoprotein of 62 kDa and 396 amino acids. It contains four domains: a Gla-rich region, two EGF-like domains, and a trypsin-like domain lacking catalytic serine residue.
Protein Z participates in the coagulation cascade and assists in the degradation of factor Xa through protein Z-related protease inhibitor (ZPI), enhancing the reaction rate approximately 1000-fold.
Deficiency of protein Z has been variably associated with both thrombosis and bleeding tendencies. It is structurally related to serine proteases such as factors VII, IX, X, and protein C.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.