Thermo Fisher Scientific PROZ Monoclonal Antibody (OTI1A11), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PROZ (Protein Z) is a vitamin K-dependent plasma glycoprotein (~62 kDa, 396 amino acids) consisting of four domains: a Gla-rich region, two EGF-like domains, and a trypsin-like domain.
Although structurally related to serine proteases (factors VII, IX, X, and protein C), it lacks catalytic activity. It participates in the coagulation cascade and enhances degradation of factor Xa via protein Z-related protease inhibitor (ZPI).
Deficiency states may be associated with either thrombosis or bleeding tendencies.
Functionality is impaired under warfarin therapy due to its vitamin K dependence.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.