Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBioTC11-18H10.1), Alexa Fluor 488, eBioscience
마우스 IL-17A를 인식하는 중화능 단클론 항체로, Alexa Fluor 488 형광 표지되어 있습니다. Flow cytometry, ELISA, ELISPOT 등 다양한 면역 분석에 적합하며, 염증성 사이토카인 연구에 활용됩니다. 4°C 보관, 동결 금지.
- 카탈로그번호
- 53-7172-80
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBioTC11-18H10.1), Alexa Fluor 488, eBioscience
Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBioTC11-18H10.1), Alexa Fluor 488
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.50 µg/test | View 1 publication |
| Inhibition Assays (IA) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), Alexa Fluor™ 488 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioTC11-18H10.1 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_493960 |
Product Specific Information
The eBioTC11-18H10.1 antibody reacts with mouse IL-17A and is a neutralizing antibody.
Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine promoting inflammatory responses and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
Human IL-17A exists as glycosylated 20–30 kDa homodimers and enhances expression of ICAM-1 in fibroblasts. It also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
IL-23-dependent, IL-17A-producing CD4+ T cells (Th-17 cells) represent a distinct subset of Th cells. IFN-γ and IL-4 negatively regulate Th-17 cell generation.
Applications Reported:
- Capture antibody in mouse IL-17A ELISA and ELISPOT assays
- Neutralization of IL-17A bioactivity
- Intracellular staining for flow cytometric analysis
Applications Tested:
Fluorochrome-conjugated eBioTC11-18H10.1 antibody tested by intracellular staining for flow cytometry. Use ≤0.50 µg per test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test.
Careful titration recommended for optimal performance.
Optical Properties:
Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in autoimmune and inflammatory diseases.
IL-17A is a 32 kDa disulfide-linked homodimer (136 amino acids) and signals through IL-17R/CDw217.
It regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.