Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES3-9D7), Alexa Fluor 488, eBioscience
인간 IL-10을 인식하는 JES3-9D7 단클론 항체로 Alexa Fluor 488 형광 표지됨. 세포내 염색 및 유세포분석에 최적화. 5 µL/test로 사용 가능하며, 4°C 암소 보관. 면역조절 및 염증 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 2 publications |
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | 11 publications |
| ELISA | - | 4 publications |
| Functional Assay | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), Alexa Fluor™ 488, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | JES3-9D7 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation/Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1834348 |
Available Formats
- Unconjugated
- Brilliant UV 395
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 480
- Brilliant Violet 711
- eFluor 450
- eFluor 660
- Functional Grade
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
Description:
The JES3-9D7 monoclonal antibody reacts with human interleukin-10 (IL-10).
Applications Reported:
This antibody is reported for use in intracellular staining followed by flow cytometric analysis.
Applications Tested:
Pre-titrated and validated for intracellular staining and flow cytometry. Recommended usage is 5 µL (0.125 µg) per test. A test is defined as the amount of antibody that stains a cell sample in a final volume of 100 µL, with cell counts ranging from 10⁵–10⁸ cells/test.
Fluorescence Information:
Excitation: 488 nm
Emission: 519 nm
Laser: Blue Laser
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
IL-10 encodes a cytokine primarily produced by monocytes and some lymphocytes. It regulates immune responses and inflammation by down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. IL-10 enhances B cell survival, proliferation, and antibody production, blocks NF-kappa B activity, and modulates the JAK-STAT signaling pathway. Knockout studies indicate IL-10 is essential for intestinal immune regulation. Mutations are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis. Associated diseases include Graft-Versus-Host Disease and HIV Type 1 infection.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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