Thermo Fisher Scientific MYH7 Polyclonal Antibody
Rabbit polyclonal antibody recognizing MYH7/beta-MHC in human, mouse, and rat. Suitable for WB, IHC(P), and ICC/IF. Affinity purified with >95% purity. Supplied as liquid in PBS with glycerol and sodium azide. For research use only.
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- PA576225
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human MYH7/beta-MHC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2719952 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Muscle myosin is a hexameric protein composed of two heavy chain subunits, two alkali light chain subunits, and two regulatory light chain subunits.
The MYH7 gene encodes the beta (or slow) heavy chain subunit of cardiac myosin, predominantly expressed in normal human ventricle and in skeletal muscle tissues rich in slow-twitch type I fibers.
Alterations in MYH7 expression correlate with cardiac contractile velocity and are influenced by thyroid hormone status and hemodynamic load.
Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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