Thermo Fisher Scientific NPDC1 Monoclonal Antibody (16E4)
NPDC1 단백질을 인식하는 마우스 단클론 항체로, Western blot 등 연구용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 1 mg/mL 액상 형태로 제공됩니다. PBS(pH 7.5)와 글리세롤 기반 버퍼에 보관되며, 뇌 조직 라이세이트를 양성 대조군으로 사용할 수 있습니다.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16E4 |
| Immunogen | Synthetic peptide corresponding to human NPDC-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage buffer | PBS, pH 7.5, with 50% glycerol |
| Contains | 3 mM sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2157042 |
Product Specific Information
A suggested positive control for this product is brain tissue lysate.
Target Information
The discovery of NPDC-1 (neuronal proliferation, differentiation and control protein 1) was the result of a study of genes preferentially expressed in immortalized neural precursor cell lines at the onset of contact inhibition of proliferation and differentiation. Transfection of transformed cells with NPDC-1 led to increased doubling times and suppression of many characteristics of transformation.
NPDC-1 is differentially expressed in brain and lung and interacts directly with transcription factor E2F-1, D-type cyclins, and cdk2. It acts as a modulator of transcriptional events mediated by retinoic acid, and its protein level and activity are regulated by phosphorylation-mediated proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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